{"id":4345,"date":"2025-09-15T14:16:54","date_gmt":"2025-09-15T14:16:54","guid":{"rendered":"https:\/\/cdtrp1.test.mobis.io\/projets-de-recherche\/pontiac\/"},"modified":"2025-09-29T18:11:48","modified_gmt":"2025-09-29T18:11:48","slug":"pontiac","status":"publish","type":"page","link":"https:\/\/canih.ca\/fr\/projets-de-recherche\/pontiac\/","title":{"rendered":"PONTIAC"},"content":{"rendered":"<div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 fusion-flex-container has-pattern-background has-mask-background nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-stretch fusion-flex-content-wrap\" style=\"max-width:1372.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_3_4 3_4 fusion-flex-column\" style=\"--awb-padding-bottom:60px;--awb-bg-size:cover;--awb-width-large:75%;--awb-margin-top-large:0px;--awb-spacing-right-large:2.56%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:2.56%;--awb-width-medium:75%;--awb-order-medium:0;--awb-spacing-right-medium:2.56%;--awb-spacing-left-medium:2.56%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-title title fusion-title-1 fusion-sep-none fusion-title-text fusion-title-size-one\" style=\"--awb-margin-bottom-small:20px;--awb-font-size:var(--awb-typography1-font-size);\"><h1 class=\"fusion-title-heading title-heading-left\" style=\"font-family:var(--awb-typography1-font-family);font-weight:var(--awb-typography1-font-weight);font-style:var(--awb-typography1-font-style);margin:0;letter-spacing:var(--awb-typography1-letter-spacing);text-transform:var(--awb-typography1-text-transform);font-size:1em;line-height:var(--awb-typography1-line-height);\">PONTIAC<\/h1><\/div><div class=\"fusion-text fusion-text-1\" style=\"--awb-font-size:var(--awb-typography2-font-size);--awb-line-height:var(--awb-typography2-line-height);--awb-letter-spacing:var(--awb-typography2-letter-spacing);--awb-text-transform:var(--awb-typography2-text-transform);--awb-text-font-family:var(--awb-typography2-font-family);--awb-text-font-weight:var(--awb-typography2-font-weight);--awb-text-font-style:var(--awb-typography2-font-style);\"><p>Prevention of Nephrotoxin-induced Acute Kidney Injury with Cilastatin (PONTIAC) Trial<\/p>\n<\/div><div class=\"fusion-title title fusion-title-2 fusion-sep-none fusion-title-text fusion-title-size-four\" style=\"--awb-margin-bottom:30px;\"><h4 class=\"fusion-title-heading title-heading-left\" style=\"margin:0;\">Contexte<\/h4><\/div><div class=\"fusion-builder-row fusion-builder-row-inner fusion-row fusion-flex-align-items-stretch fusion-flex-content-wrap\" style=\"width:104% !important;max-width:104% !important;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column_inner fusion-builder-nested-column-0 fusion_builder_column_inner_1_1 1_1 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><ul style=\"--awb-margin-top:0px;--awb-item-padding-top:30px;--awb-item-padding-right:30px;--awb-item-padding-bottom:30px;--awb-item-padding-left:20px;--awb-even-row-bgcolor:var(--awb-color2);--awb-iconcolor:var(--awb-color5);--awb-line-height:27.2px;--awb-icon-width:27.2px;--awb-icon-height:27.2px;--awb-icon-margin:11.2px;--awb-content-margin:38.4px;\" class=\"fusion-checklist fusion-checklist-1 type-icons\"><li class=\"fusion-li-item\" style=\"\"><span class=\"icon-wrapper circle-no\"><i class=\"fusion-li-icon awb-business-long-arrow-alt-right-solid\" aria-hidden=\"true\"><\/i><\/span><div class=\"fusion-li-item-content\">\n<p>De nombreux m\u00e9dicaments sont n\u00e9cessaires pour traiter diverses affections chez les personnes hospitalis\u00e9es. Certains peuvent toutefois endommager les reins, entra\u00eenant des complications qui m\u00e8nent \u00e0 des maladies r\u00e9nales et cardiaques.<\/p>\n<\/div><\/li><li class=\"fusion-li-item\" style=\"\"><span class=\"icon-wrapper circle-no\"><i class=\"fusion-li-icon awb-business-long-arrow-alt-right-solid\" aria-hidden=\"true\"><\/i><\/span><div class=\"fusion-li-item-content\">\n<p>Notre \u00e9quipe a identifi\u00e9 un m\u00e9dicament, la cilastatine, qui emp\u00eache l\u2019accumulation de ces substances dans les reins et pr\u00e9vient l\u2019inflammation menant \u00e0 ces maladies.<\/p>\n<\/div><\/li><\/ul><\/div><\/div><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:30px;margin-bottom:30px;width:100%;\"><\/div><div class=\"fusion-title title fusion-title-3 fusion-sep-none fusion-title-text fusion-title-size-four\" style=\"--awb-margin-top:60px;--awb-margin-bottom:30px;--awb-margin-top-small:60px;--awb-margin-bottom-small:30px;\"><h4 class=\"fusion-title-heading title-heading-left\" style=\"margin:0;\">Objectif de l\u2019\u00e9tude<\/h4><\/div><div class=\"fusion-builder-row fusion-builder-row-inner fusion-row fusion-flex-align-items-stretch fusion-flex-content-wrap\" style=\"width:104% !important;max-width:104% !important;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column_inner fusion-builder-nested-column-1 fusion_builder_column_inner_1_1 1_1 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><ul style=\"--awb-margin-top:0px;--awb-item-padding-top:30px;--awb-item-padding-right:30px;--awb-item-padding-bottom:30px;--awb-item-padding-left:20px;--awb-even-row-bgcolor:var(--awb-color2);--awb-iconcolor:var(--awb-color5);--awb-line-height:27.2px;--awb-icon-width:27.2px;--awb-icon-height:27.2px;--awb-icon-margin:11.2px;--awb-content-margin:38.4px;\" class=\"fusion-checklist fusion-checklist-2 type-icons\"><li class=\"fusion-li-item\" style=\"\"><span class=\"icon-wrapper circle-no\"><i class=\"fusion-li-icon awb-business-long-arrow-alt-right-solid\" aria-hidden=\"true\"><\/i><\/span><div class=\"fusion-li-item-content\">\n<p>Le cilastatine est d\u00e9j\u00e0 utilis\u00e9 pour d\u2019autres raisons et est consid\u00e9r\u00e9 comme s\u00fbr, mais il n\u2019a pas encore \u00e9t\u00e9 test\u00e9 pour d\u00e9terminer s\u2019il peut pr\u00e9venir les l\u00e9sions r\u00e9nales, puis les maladies r\u00e9nales et cardiaques, chez les personnes expos\u00e9es \u00e0 des m\u00e9dicaments n\u00e9phrotoxiques.<\/p>\n<\/div><\/li><li class=\"fusion-li-item\" style=\"\"><span class=\"icon-wrapper circle-no\"><i class=\"fusion-li-icon awb-business-long-arrow-alt-right-solid\" aria-hidden=\"true\"><\/i><\/span><div class=\"fusion-li-item-content\">\n<p>Cette \u00e9tude recrutera des patients trait\u00e9s par de tels m\u00e9dicaments et les r\u00e9partira au hasard en deux groupes : l\u2019un recevra du cilastatine et l\u2019autre un placebo (par exemple, de l\u2019eau). L\u2019\u00e9tude d\u00e9terminera si le groupe trait\u00e9 au cilastatine pr\u00e9sente de meilleurs r\u00e9sultats de sant\u00e9 que le groupe placebo.<\/p>\n<\/div><\/li><\/ul><\/div><\/div><\/div><\/div><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-1 fusion_builder_column_1_4 1_4 fusion-flex-column\" style=\"--awb-padding-top:1rem;--awb-padding-right:1rem;--awb-padding-bottom:1rem;--awb-padding-left:1rem;--awb-bg-color:var(--awb-color2);--awb-bg-color-hover:var(--awb-color2);--awb-bg-size:cover;--awb-width-large:25%;--awb-margin-top-large:0px;--awb-spacing-right-large:7.68%;--awb-margin-bottom-large:20px;--awb-spacing-left-large:7.68%;--awb-width-medium:25%;--awb-order-medium:0;--awb-spacing-right-medium:7.68%;--awb-spacing-left-medium:7.68%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\" data-scroll-devices=\"small-visibility,medium-visibility,large-visibility\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-title title fusion-title-4 sep-underline sep-solid fusion-title-text fusion-title-size-three\" style=\"--awb-font-size:var(--awb-typography2-font-size);\"><h3 class=\"fusion-title-heading title-heading-left\" style=\"font-family:var(--awb-typography2-font-family);font-weight:var(--awb-typography2-font-weight);font-style:var(--awb-typography2-font-style);margin:0;letter-spacing:var(--awb-typography2-letter-spacing);text-transform:var(--awb-typography2-text-transform);font-size:1em;line-height:var(--awb-typography2-line-height);\">\u00c0 propos de l\u2019\u00e9tude<\/h3><\/div><div class=\"fusion-image-element \" style=\"--awb-caption-title-font-family:var(--h2_typography-font-family);--awb-caption-title-font-weight:var(--h2_typography-font-weight);--awb-caption-title-font-style:var(--h2_typography-font-style);--awb-caption-title-size:var(--h2_typography-font-size);--awb-caption-title-transform:var(--h2_typography-text-transform);--awb-caption-title-line-height:var(--h2_typography-line-height);--awb-caption-title-letter-spacing:var(--h2_typography-letter-spacing);\"><span class=\" fusion-imageframe imageframe-none imageframe-1 hover-type-none\"><img decoding=\"async\" src=\"data:image\/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==\" data-orig-src=\"https:\/\/canih.ca\/wp-content\/uploads\/2025\/09\/dr.-matthew-thomas-james.jpg\" alt class=\"lazyload img-responsive wp-image-3615\"\/><\/span><\/div><div class=\"fusion-text fusion-text-2 fusion-text-no-margin\" style=\"--awb-content-alignment:center;--awb-margin-top:1.5rem;\"><p>Matthew T James<\/p>\n<\/div><div class=\"fusion-text fusion-text-3\" style=\"--awb-content-alignment:center;\"><p>University of Calgary<\/p>\n<\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;width:100%;\"><div class=\"fusion-separator-border sep-single sep-solid\" style=\"--awb-height:20px;--awb-amount:20px;border-color:var(--awb-color3);border-top-width:1px;\"><\/div><\/div><div style=\"text-align:center;\"><a class=\"fusion-button button-flat button-medium button-default fusion-button-default button-1 fusion-button-default-span fusion-button-default-type\" style=\"--button_margin-top:1.5rem;\" target=\"_blank\" rel=\"noopener noreferrer\" href=\"https:\/\/www.archbiopartners.com\/2024\/08\/02\/arch-biopartners-cilastatin-drug-candidate-to-participate-in-the-pontiac-phase-ii-trial-targeting-acute-kidney-injury-caused-by-drug-toxins\/ \"><span class=\"fusion-button-text awb-button__text awb-button__text--default\">Pour en savoir plus<\/span><\/a><\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":4312,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"100-width.php","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-4345","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.4 - 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