{"id":3821,"date":"2025-09-15T15:53:44","date_gmt":"2025-09-15T15:53:44","guid":{"rendered":"https:\/\/cdtrp1.test.mobis.io\/?page_id=3821"},"modified":"2025-09-25T09:53:30","modified_gmt":"2025-09-25T09:53:30","slug":"closing-the-comorbidity-gap-for-people-living-with-hiv-a-randomized-controlled-trial-of-fostemsavir-to-reduce-inflammaging","status":"publish","type":"page","link":"https:\/\/canih.ca\/en\/research-projects\/closing-the-comorbidity-gap-for-people-living-with-hiv-a-randomized-controlled-trial-of-fostemsavir-to-reduce-inflammaging\/","title":{"rendered":"Closing the Comorbidity Gap for People Living with HIV"},"content":{"rendered":"<p><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-padding-top:60px;--awb-padding-bottom:60px;--awb-padding-top-medium:40px;--awb-padding-bottom-medium:40px;--awb-padding-top-small:12px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-center fusion-flex-content-wrap\" style=\"max-width:1372.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_2_5 2_5 fusion-flex-column fusion-animated\" style=\"--awb-bg-size:cover;--awb-width-large:40%;--awb-margin-top-large:0px;--awb-spacing-right-large:14.4%;--awb-margin-bottom-large:20px;--awb-spacing-left-large:4.8%;--awb-width-medium:50%;--awb-order-medium:0;--awb-spacing-right-medium:0%;--awb-spacing-left-medium:3.84%;--awb-width-small:100%;--awb-margin-top-small:10px;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\" data-animationType=\"fadeInRight\" data-animationDuration=\"1.6\" data-animationOffset=\"top-into-view\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-title title fusion-title-1 fusion-sep-none fusion-title-text fusion-title-size-one\" style=\"--awb-margin-top:6px;--awb-font-size:var(--awb-typography1-font-size);\"><h1 class=\"fusion-title-heading title-heading-left\" style=\"font-family:var(--awb-typography1-font-family);font-weight:var(--awb-typography1-font-weight);font-style:var(--awb-typography1-font-style);margin:0;letter-spacing:var(--awb-typography1-letter-spacing);text-transform:var(--awb-typography1-text-transform);font-size:1em;line-height:var(--awb-typography1-line-height);\">Closing the Comorbidity Gap for People Living with HIV<\/h1><\/div><div class=\"fusion-text fusion-text-1\" style=\"--awb-content-alignment:left;--awb-font-size:var(--awb-typography2-font-size);--awb-line-height:var(--awb-typography2-line-height);--awb-letter-spacing:var(--awb-typography2-letter-spacing);--awb-text-transform:var(--awb-typography2-text-transform);--awb-text-font-family:var(--awb-typography2-font-family);--awb-text-font-weight:var(--awb-typography2-font-weight);--awb-text-font-style:var(--awb-typography2-font-style);\"><p>A Randomized Controlled Trial of Fostemsavir to Reduce Inflammaging<\/p>\n<\/div><\/div><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-1 fusion_builder_column_3_5 3_5 fusion-flex-column fusion-animated\" style=\"--awb-padding-top:25rem;--awb-padding-top-medium:360px;--awb-bg-color:var(--awb-color2);--awb-bg-color-hover:var(--awb-color2);--awb-bg-position:center top;--awb-bg-size:540px;--awb-box-shadow:72px 72px 0px 0px var(--awb-color2);;--awb-width-large:60%;--awb-margin-top-large:0px;--awb-spacing-right-large:16%;--awb-margin-bottom-large:20px;--awb-spacing-left-large:9.6%;--awb-width-medium:50%;--awb-order-medium:0;--awb-spacing-right-medium:3.84%;--awb-spacing-left-medium:11.52%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\" data-animationType=\"fadeInRight\" data-animationDuration=\"1.6\" data-animationOffset=\"top-into-view\" data-scroll-devices=\"small-visibility,medium-visibility,large-visibility\"><div class=\"fusion-column-wrapper lazyload fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column fusion-column-has-bg-image\" data-bg-url=\"https:\/\/canih.ca\/wp-content\/uploads\/2025\/09\/madeleine-durand_4.webp\" data-bg=\"https:\/\/canih.ca\/wp-content\/uploads\/2025\/09\/madeleine-durand_4.webp\"><div class=\"fusion-builder-row fusion-builder-row-inner fusion-row fusion-flex-align-items-center fusion-flex-content-wrap\" style=\"width:104% !important;max-width:104% !important;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column_inner fusion-builder-nested-column-0 fusion_builder_column_inner_1_2 1_2 fusion-flex-column\" style=\"--awb-padding-top:30px;--awb-padding-right:30px;--awb-padding-bottom:10px;--awb-padding-left:30px;--awb-bg-color:var(--awb-color1);--awb-bg-color-hover:var(--awb-color1);--awb-bg-size:cover;--awb-box-shadow:44px 44px 50px 0px hsla(var(--awb-color8-h),var(--awb-color8-s),var(--awb-color8-l),calc( var(--awb-color8-a) - 85% ));;--awb-width-large:50%;--awb-margin-top-large:0px;--awb-spacing-right-large:0%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:3.84%;--awb-width-medium:75%;--awb-order-medium:0;--awb-spacing-right-medium:0%;--awb-spacing-left-medium:2.56%;--awb-width-small:75%;--awb-order-small:0;--awb-spacing-right-small:0%;--awb-spacing-left-small:2.56%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-title title fusion-title-2 fusion-sep-none fusion-title-text fusion-title-size-six\" style=\"--awb-margin-top:0px;--awb-margin-bottom:4px;--awb-margin-top-small:4px;--awb-margin-bottom-small:0px;--awb-margin-top-medium:4px;--awb-margin-bottom-medium:0px;\"><h6 class=\"fusion-title-heading title-heading-left\" style=\"margin:0;\">Madeleine Durand<\/h6><\/div><div class=\"fusion-text fusion-text-2\" style=\"--awb-content-alignment:left;--awb-font-size:14px;--awb-line-height:24px;\"><p>University of Montreal<\/p>\n<\/div><\/div><\/div><div class=\"fusion-layout-column fusion_builder_column_inner fusion-builder-nested-column-1 fusion_builder_column_inner_1_2 1_2 fusion-flex-column fusion-no-small-visibility\" style=\"--awb-bg-size:cover;--awb-width-large:50%;--awb-margin-top-large:0px;--awb-spacing-right-large:3.84%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:3.84%;--awb-width-medium:25%;--awb-order-medium:0;--awb-spacing-right-medium:7.68%;--awb-spacing-left-medium:7.68%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><\/div><\/div><\/div><\/div><\/div><\/div><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-2 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-padding-top:4%;--awb-padding-top-medium:40px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-content-wrap\" style=\"max-width:1372.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-2 fusion_builder_column_1_1 1_1 fusion-flex-column fusion-animated\" style=\"--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:10px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:20px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-margin-bottom-medium:10px;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-margin-top-small:0px;--awb-spacing-right-small:1.92%;--awb-margin-bottom-small:0px;--awb-spacing-left-small:1.92%;\" data-animationType=\"fadeInUp\" data-animationDuration=\"1.6\" data-animationOffset=\"top-into-view\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-title title fusion-title-3 fusion-sep-none fusion-title-center fusion-title-text fusion-title-size-two\" style=\"--awb-margin-bottom:16px;\"><h2 class=\"fusion-title-heading title-heading-center\" style=\"margin:0;\">Background<\/h2><\/div><div class=\"fusion-text fusion-text-3\" style=\"--awb-content-alignment:center;--awb-font-size:var(--awb-typography5-font-size);--awb-line-height:var(--awb-typography5-line-height);--awb-letter-spacing:var(--awb-typography5-letter-spacing);--awb-text-transform:var(--awb-typography5-text-transform);--awb-margin-top:1rem;--awb-text-font-family:var(--awb-typography5-font-family);--awb-text-font-weight:var(--awb-typography5-font-weight);--awb-text-font-style:var(--awb-typography5-font-style);\"><p>HIV is a chronic manageable disease, but it remains incurable. As a result, aging well with HIV is a public health priority.<\/p>\n<\/div><div class=\"fusion-text fusion-text-4\" style=\"--awb-content-alignment:center;--awb-font-size:var(--awb-typography5-font-size);--awb-line-height:var(--awb-typography5-line-height);--awb-letter-spacing:var(--awb-typography5-letter-spacing);--awb-text-transform:var(--awb-typography5-text-transform);--awb-text-font-family:var(--awb-typography5-font-family);--awb-text-font-weight:var(--awb-typography5-font-weight);--awb-text-font-style:var(--awb-typography5-font-style);\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-6 fusion_builder_column_1_2 1_2 fusion-flex-column\">\n<div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\">\n<div class=\"fusion-text fusion-text-2\">\n<p>The study population of this research project are people living with HIV with undetectable viral load, and the overarching goal of this program is to close the prognostic gap for these people, so that they may have an optimal health related quality of life.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-3 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-padding-top:4%;--awb-padding-top-medium:40px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-content-wrap\" style=\"max-width:1372.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-3 fusion_builder_column_1_1 1_1 fusion-flex-column fusion-animated\" style=\"--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:10px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:20px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-margin-bottom-medium:10px;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-margin-top-small:0px;--awb-spacing-right-small:1.92%;--awb-margin-bottom-small:0px;--awb-spacing-left-small:1.92%;\" data-animationType=\"fadeInUp\" data-animationDuration=\"1.6\" data-animationOffset=\"top-into-view\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-title title fusion-title-4 fusion-sep-none fusion-title-center fusion-title-text fusion-title-size-two\" style=\"--awb-margin-bottom:16px;\"><h2 class=\"fusion-title-heading title-heading-center\" style=\"margin:0;\">What is the main aim of the study?<\/h2><\/div><div class=\"fusion-text fusion-text-5\" style=\"--awb-content-alignment:center;--awb-font-size:var(--awb-typography5-font-size);--awb-line-height:var(--awb-typography5-line-height);--awb-letter-spacing:var(--awb-typography5-letter-spacing);--awb-text-transform:var(--awb-typography5-text-transform);--awb-margin-top:1rem;--awb-text-font-family:var(--awb-typography5-font-family);--awb-text-font-weight:var(--awb-typography5-font-weight);--awb-text-font-style:var(--awb-typography5-font-style);\"><p>At present, no intervention has been shown effective to reduce the risk of cardiovascular disease that is secondary to the chronic inflammation present in people living with HIV.<\/p>\n<\/div><div class=\"fusion-text fusion-text-6\" style=\"--awb-content-alignment:center;--awb-font-size:var(--awb-typography5-font-size);--awb-line-height:var(--awb-typography5-line-height);--awb-letter-spacing:var(--awb-typography5-letter-spacing);--awb-text-transform:var(--awb-typography5-text-transform);--awb-margin-top:1rem;--awb-text-font-family:var(--awb-typography5-font-family);--awb-text-font-weight:var(--awb-typography5-font-weight);--awb-text-font-style:var(--awb-typography5-font-style);\"><div class=\"fusion-text fusion-text-3\">\n<p>It will establish whether treatment with fostemsavir can reduce inflammation and comorbidities such as cardiovascular disease in this population.<\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":3555,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"100-width.php","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-3821","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.4 - 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